EUS (Endoscopic Ultrasound)-guided gallbladder drainage is a minimally invasive procedure performed to alleviate symptoms associated with acute or chronic cholecystitis (inflammation of the gallbladder) when conventional treatment options are not feasible. During the procedure, an endoscope equipped with an ultrasound probe is inserted through the mouth and advanced into the duodenum. Using real-time ultrasound imaging, the gastroenterologist identifies the gallbladder and locates a suitable puncture site on its wall. A needle is then passed through the endoscope and used to puncture the gallbladder, creating a tract through which a stent is inserted to allow bile drainage into the small intestine. EUS-guided gallbladder drainage is particularly beneficial for patients who are not candidates for surgery or ERCP (Endoscopic Retrograde Cholangiopancreatography)-based interventions due to anatomical variations, prior surgeries, or failed cannulation. The procedure is associated with a high technical success rate and provides effective relief from symptoms such as abdominal pain, fever, and jaundice, thus improving the patient's quality of life. However, like any medical procedure, EUS-guided gallbladder drainage carries some risks, including bleeding, infection, and stent migration, which are minimized through careful patient selection and procedural expertise. Overall, EUS-guided gallbladder drainage represents a valuable therapeutic option for patients with gallbladder-related disorders, offering an alternative to surgical intervention with favorable outcomes and minimal invasiveness.